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Pulmonary eosinophilia

MedGen UID:
46208
•Concept ID:
C0034068
•
Disease or Syndrome
Synonyms: Eosinophilia, Pulmonary; Eosinophilias, Pulmonary; Pulmonary Eosinophilia; Pulmonary Eosinophilias
SNOMED CT: PIE - Pulmonary infiltrates with eosinophilia (367542003); Pulmonary infiltrates with eosinophilia (367542003); Andrews syndrome (367542003); Pulmonary eosinophilia (367542003)
 
Monarch Initiative: MONDO:0004802

Definition

A condition characterized by infiltration of the lung with eosinophils due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary eosinophilia

Professional guidelines

PubMed

Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting.
Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
Chest 2022 Nov;162(5):1188-1198. Epub 2022 Jun 1 doi: 10.1016/j.chest.2022.05.035. PMID: 35661746
Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia.
Zimmermann N, Wikenheiser-Brokamp KA
Ann Allergy Asthma Immunol 2018 Aug;121(2):179-185. Epub 2018 May 24 doi: 10.1016/j.anai.2018.05.014. PMID: 29803709
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

Recent clinical studies

Etiology

Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5.
Moermans C, Brion C, Bock G, Graff S, Gerday S, Nekoee H, Poulet C, Bricmont N, Henket M, Paulus V, Guissard F, Louis R, Schleich F
Chest 2023 Jun;163(6):1368-1379. Epub 2023 Feb 3 doi: 10.1016/j.chest.2023.01.037. PMID: 36740095
Diagnosis and Assessment of the Asthmas.
Pavord ID, Barnes PJ, Lemière C, Gibson PG
J Allergy Clin Immunol Pract 2023 Jan;11(1):1-8. Epub 2022 Oct 3 doi: 10.1016/j.jaip.2022.09.034. PMID: 36195258
Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide.
Couillard S, Laugerud A, Jabeen M, Ramakrishnan S, Melhorn J, Hinks T, Pavord I
Thorax 2022 Feb;77(2):199-202. Epub 2021 Aug 6 doi: 10.1136/thoraxjnl-2021-217325. PMID: 34362839Free PMC Article
Stopping versus continuing long-term mepolizumab treatment in severe eosinophilic asthma (COMET study).
Moore WC, Kornmann O, Humbert M, Poirier C, Bel EH, Kaneko N, Smith SG, Martin N, Gilson MJ, Price RG, Bradford ES, Liu MC
Eur Respir J 2022 Jan;59(1) Epub 2022 Jan 6 doi: 10.1183/13993003.00396-2021. PMID: 34172470Free PMC Article
Eosinophilic Asthma.
Nelson RK, Bush A, Stokes J, Nair P, Akuthota P
J Allergy Clin Immunol Pract 2020 Feb;8(2):465-473. Epub 2019 Nov 28 doi: 10.1016/j.jaip.2019.11.024. PMID: 31786254

Diagnosis

Eosinophilic Lung Diseases.
Cottin V
Immunol Allergy Clin North Am 2023 May;43(2):289-322. doi: 10.1016/j.iac.2023.01.002. PMID: 37055090
Eosinophilic Lung Diseases.
Cottin V
Clin Chest Med 2016 Sep;37(3):535-56. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.015. PMID: 27514599
Eosinophilic lung diseases.
Fernández Pérez ER, Olson AL, Frankel SK
Med Clin North Am 2011 Nov;95(6):1163-87. doi: 10.1016/j.mcna.2011.08.006. PMID: 22032433
Pulmonary eosinophilia.
Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481
Eosinophilic pneumonias.
Cottin V, Cordier JF
Allergy 2005 Jul;60(7):841-57. doi: 10.1111/j.1398-9995.2005.00812.x. PMID: 15932372

Therapy

Eosinophilic Asthma.
Nelson RK, Bush A, Stokes J, Nair P, Akuthota P
J Allergy Clin Immunol Pract 2020 Feb;8(2):465-473. Epub 2019 Nov 28 doi: 10.1016/j.jaip.2019.11.024. PMID: 31786254
Pulmonary eosinophilia.
Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481
Acute eosinophilic pneumonia.
Allen J
Semin Respir Crit Care Med 2006 Apr;27(2):142-7. doi: 10.1055/s-2006-939517. PMID: 16612765
Eosinophilic pneumonias.
Cottin V, Cordier JF
Allergy 2005 Jul;60(7):841-57. doi: 10.1111/j.1398-9995.2005.00812.x. PMID: 15932372
Pulmonary eosinophilia.
Lancet 1990 Mar 3;335(8688):512. PMID: 1968535

Prognosis

Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide.
Couillard S, Laugerud A, Jabeen M, Ramakrishnan S, Melhorn J, Hinks T, Pavord I
Thorax 2022 Feb;77(2):199-202. Epub 2021 Aug 6 doi: 10.1136/thoraxjnl-2021-217325. PMID: 34362839Free PMC Article
Eosinophilic bronchitis without asthma.
Gonlugur U, Gonlugur TE
Int Arch Allergy Immunol 2008;147(1):1-5. Epub 2008 Apr 30 doi: 10.1159/000128580. PMID: 18446047
Pulmonary eosinophilia.
Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481
Acute eosinophilic pneumonia.
Allen J
Semin Respir Crit Care Med 2006 Apr;27(2):142-7. doi: 10.1055/s-2006-939517. PMID: 16612765
Eosinophilic pneumonias.
Cottin V, Cordier JF
Allergy 2005 Jul;60(7):841-57. doi: 10.1111/j.1398-9995.2005.00812.x. PMID: 15932372

Clinical prediction guides

Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide.
Couillard S, Laugerud A, Jabeen M, Ramakrishnan S, Melhorn J, Hinks T, Pavord I
Thorax 2022 Feb;77(2):199-202. Epub 2021 Aug 6 doi: 10.1136/thoraxjnl-2021-217325. PMID: 34362839Free PMC Article
Stopping versus continuing long-term mepolizumab treatment in severe eosinophilic asthma (COMET study).
Moore WC, Kornmann O, Humbert M, Poirier C, Bel EH, Kaneko N, Smith SG, Martin N, Gilson MJ, Price RG, Bradford ES, Liu MC
Eur Respir J 2022 Jan;59(1) Epub 2022 Jan 6 doi: 10.1183/13993003.00396-2021. PMID: 34172470Free PMC Article
Targeted biologic therapy for asthma.
Hynes G, Pavord ID
Br Med Bull 2020 May 15;133(1):16-35. doi: 10.1093/bmb/ldaa004. PMID: 32318701
Biomarkers for severe eosinophilic asthma.
Yancey SW, Keene ON, Albers FC, Ortega H, Bates S, Bleecker ER, Pavord I
J Allergy Clin Immunol 2017 Dec;140(6):1509-1518. doi: 10.1016/j.jaci.2017.10.005. PMID: 29221581
Clarithromycin-induced eosinophilic pneumonia.
Ohnishi H, Abe M, Yokoyama A, Hamada H, Ito R, Hirayama T, Nishimura K, Higaki J
Intern Med 2004 Mar;43(3):231-5. doi: 10.2169/internalmedicine.43.231. PMID: 15098607

Recent systematic reviews

Daptomycin-Induced Eosinophilic Pneumonia: A Case Report and Systematic Review.
Di Lorenzo A, Rindi LV, Campogiani L, Imeneo A, Alessio G, Pace PG, Lodi A, Rossi B, Crea AMA, Vitale P, Kontogiannis D, Malagnino V, Andreoni M, Iannetta M, Sarmati L
Chemotherapy 2024;69(2):85-99. Epub 2023 Nov 14 doi: 10.1159/000535190. PMID: 37963447
Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis.
Scott HA, Ng SH, McLoughlin RF, Valkenborghs SR, Nair P, Brown AC, Carroll OR, Horvat JC, Wood LG
Thorax 2023 Oct;78(10):957-965. Epub 2023 Mar 22 doi: 10.1136/thorax-2022-219268. PMID: 36948588
Comparative efficacy of tezepelumab to mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis.
Nopsopon T, Lassiter G, Chen ML, Alexander GC, Keet C, Hong H, Akenroye A
J Allergy Clin Immunol 2023 Mar;151(3):747-755. Epub 2022 Dec 17 doi: 10.1016/j.jaci.2022.11.021. PMID: 36538979Free PMC Article
Comparative efficacy of mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis.
Akenroye A, Lassiter G, Jackson JW, Keet C, Segal J, Alexander GC, Hong H
J Allergy Clin Immunol 2022 Nov;150(5):1097-1105.e12. Epub 2022 Jun 27 doi: 10.1016/j.jaci.2022.05.024. PMID: 35772597Free PMC Article
Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis.
Petsky HL, Cates CJ, Kew KM, Chang AB
Thorax 2018 Dec;73(12):1110-1119. Epub 2018 Jun 1 doi: 10.1136/thoraxjnl-2018-211540. PMID: 29858277

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